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Chapter 150 Bone Marrow Transplantation

It was originally scheduled to help the child undergo a bone marrow transplant at the end of the month, but because so many patients suddenly flocked to the hospital, the bone marrow transplant was postponed for three days. Fortunately, the child's parents understood the current situation of the hospital, and also knew that William was not the ideal time to help his child undergo a bone marrow transplant under such circumstances, so no unpleasant things happened.

Before bone marrow transplantation, the patient was originally required to use chemical drugs and radiation to destroy the cancer cells on the patient's body. However, at the same time, the normal hematopoietic cells in the patient's body were also killed. The human body's immunity decreased and it was very easy to cause infection, which brought great danger to bone marrow transplantation. Therefore, general bone marrow transplantation surgery must be transplanted in a sterile ward (laminar flow room). However, when Wu Tianlin was in Sweden, he specially adopted a new preparation method for this surgery. A week before the child's surgery, Wu Tianlin used a two-pronged approach to Chinese and Western medicine to cut off the oxygen supply system of the cancer cell in the child's body with Western medicine, and then slowly eliminated the cancer cells in the child's body with Chinese medicine. Although the whole process was a bit long, this method would not harm the normal hematopoietic cells of the human body, so that the human body's immune ability would be guaranteed to a certain extent before the operation, and played an important role in the success rate of the operation.

Before a conventional bone marrow transplant, only hla-a, b, and dr is the same. Since the diversity of hla-ab is the most obvious, Wu Tianlin arranged for the children's relatives to do hla-ab classification at that time, but none of them could be completely matched with the children's hla, so he could only use other ways to find bone marrow that is completely matched with the children. Although the matching bone marrow was finally found, it also means that this bone marrow transplant surgery was a non-kind bone marrow transplant surgery. The general non-kind bone marrow transplant surgery is one in 100,000 because the probability of matching hematopoietic stem cells between donors and patients is one in 100,000, so bone marrow transplantation can be successfully achieved.

It is not easy. Different degrees of rejection reactions will occur during the transplantation process, because the immune system can distinguish "alien" from foreign objects, attack it, and exclude it. This process is called "rejection reaction". In order to ensure the success of the operation, Wu Tianlin did not use conventional chemotherapy to eliminate cancer cells in the child's body before the operation, so that the child's immune system can be protected to a certain extent. However, it also increases the probability of rejection reactions during the bone marrow transplantation process. However, although gvhd is dangerous to patients, it has anti-leukemia effects, which can reduce the recurrence of leukemia after transplantation, and can better save the patient.

At around 10 o'clock in the morning, Wu Tianlin, William and two nurses went into the laminar flow room prepared for disinfection and walked into the laminar flow room prepared in advance. At this time, the child who had been lying in the laminar flow room for a whole week was looking at the lights on the ceiling of the laminar flow room with wide eyes. There was no fear or confusion on his face as adults were entering the operating room. Instead, he was full of curiosity. When he saw Wu Tianlin walking into the laminar flow room wearing a mask, he asked Wu Tianlin: "Uncle Wu! Can my illness be cured?"

Wu Tianlin nodded to him and replied with a smile: "Little boy! Don't worry! You only need to sleep for a while later, and uncle promises that you will be able to return to school soon."

After Wu Tianlin finished speaking, he nodded to William and the others beside him and said, "Let's start!" As he said that, Wu Tianlin took out the silver needle that had been disinfected in advance from the small box and stabbed it at several acupoints on the child's body. Not long after, the child who had already had his eyes glow suddenly became very tired and slowly closed his eyes and fell asleep.

After watching the child fall asleep, Wu Tianlin performed local anesthesia and acupuncture on the child. At this time, William had prepared the bone marrow stored in advance and injected it into the child's body from the intravenous vein. Wu Tianlin had prepared the immunosuppressive drug solution prepared in advance and carefully pushed the immunosuppressive drug solution into the child's vein when the bone marrow was implanted into the child's body.

The whole process seems simple, but only Wu Tianlin and William know how difficult it is. The time before and after the bone marrow enters the body and the immunosuppressive drug liquid enters the body must be calculated very accurately. Otherwise, the immunosuppressive drug liquid will not be able to achieve real effect, but will inhibit the reproduction of blood cells in the human body, so there is no deviation in the entire process.

After half an hour, the entire transplantation process is basically the end. The remaining time is to observe the rejection reaction during the transplantation. Because the donor and the child are non-kind, the "attack" of the recipient by the gradually growing donor immune cells will become more and more severe, and it is likely to produce a "graft-versus-host reaction". The symptoms of this gvhd include: fever, skin flushing, rash, liver and spleen enlargement, liver function abnormality, whole blood cell loss, hepatitis, severe diarrhea, bone marrow hardness and infection, and in severe cases, fatal reactions can occur. In twins, the incidence of gvhd is 1-5%, among relatives is 36%, and non-blood relationship is 50-70%.

As time goes by, the child's skin is obviously red, so at this time the donor's immune cells are attacking the immune cells in the child's body, and the child's face is also painful, and sweat is slowly oozing out of his forehead. Seeing this situation, the child's body is very serious, indicating that the effect of the immunosuppressive drug liquid injected before is not very good. Wu Tianlin immediately pulled out sixteen golden needles and stabbed several large acupoints on the child's body. At the same time, he ordered William: "William! Inject fusion agent immediately."

Upon hearing this, William immediately took out a bottle of fusion medicine made of Wu Tianlin with Chinese medicine and injected it into the child's vein again. As the fusion medicine entered, more than a dozen golden needles outside the child's body immediately triggered the fusion medicine. The red tide on the child's body began to gradually weaken, and the expression on the child's face slowly returned to normal. Seeing this situation, although Wu Tianlin had already figured out in his heart, he couldn't help but breathe a deep breath of air with the potion. He sighed and said, "The operation has finally been successful. Whether this child can recover depends on his willpower."

Time passed by minute by minute. After half an hour, the repulsion completely disappeared, which meant that the non-kindergarten bone marrow transplant surgery was truly successful. Wu Tianlin gradually smiled and said to William beside him: "William! You didn't see it when I inserted the needle just now. Now you have carefully read the techniques and steps of removing the needle." As he said that, Wu Tianlin deliberately slowed down and pulled out all sixteen golden needles and thirty-six silver needles that were inserted into the important acupoints of the child's body. He smiled and ordered to the two nurses: "Anna! Yilin! The rest is left to you. Although the hematopoietic cells implanted in the child's body have begun to reproduce and rebuild the hematopoietic and immune system, because the child's body is not very good, repulsion may occur at any time, so you must pay attention to observation."

"Teacher! We two of us have performed this type of bone marrow transplant surgery with you and William. We already know what happens to the patient after the operation, so please rest assured!" Nurse Anna replied to Wu Tianlin with a smile while packing up her things.

Since William has worked with Wu Tianlin for bone marrow transplant surgery, Wu Tianlin will prepare a bottle of fusion medicine whenever he encounters a non-relative bone marrow transplant surgery. Although this fusion medicine has not been used many times so far, the effect is very obvious. However, William is very puzzled. With such a drug with obvious effects, why didn't Wu Tianlin promote him to all bone marrow transplant surgery? You should know that the effect of this drug will make the success rate of bone marrow transplant surgery reach more than 80%. If promoted, it will undoubtedly be announced that bone marrow transplant surgery will no longer be a very difficult surgery.

Before, William thought about what configuration Wu Tianlin's fusion potion was made of, and why it was not directly applied to bone marrow transplant surgery. However, he finally swallowed it back into his stomach after several times. This time, seeing Wu Tianlin use this fusion potion again, William could no longer help but ask Wu Tianlin: "Teacher! This fusion potion is so effective, why don't you directly promote him on a large scale?"

Wu Tianlin saw that William wanted to ask this question a long time ago, but because he was afraid of involving some secret recipes from traditional Chinese medicine, he didn't ask himself. Now, seeing William finally couldn't help asking. Wu Tianlin didn't hide it privately and replied with a smile: "This medicine is only effective for severe rejection. To put it bluntly, it helps the hematopoietic cells transplanted into the human body to suppress the original cells. Under normal circumstances, using this fusion agent is not conducive to the reproduction of the transplanted hematopoietic cells in the human body. In addition, the preparation of this agent is not easy, and the complex characteristics of traditional Chinese medicine have not been fully certified in the international medical community. Even if we really want to promote it in non-relative bone marrow transplant surgery, it is not easy."

While talking, Wu Tianlin and William had already walked out of the laminar room. Mr. Tang and his wife who had been waiting outside and a large number of relatives saw Wu Tianlin and William, and immediately surrounded Wu Tianlin and William. Mr. Tang was anxious and his heart tense. He held Wu Tianlin's hand tightly, and asked nervously and urgently: "Doctor Wu! How is my son's condition? Has the bone marrow transplant successful?"

When Wu Tianlin heard this, he smiled at the people in front of him with anticipation and replied with a smile: "Mr. Tang! Do you have no confidence in yourself? Or do you not believe in our doctor William's medical skills? The operation was very successful. Although there was rejection at the beginning, it has basically stabilized now. Your son is in the observation period. As long as he does not show rejection again in the past two days, I promise that your son will go to school like a normal child in the near future."

Hearing Wu Tianlin's words, Mr. Tang and his wife were filled with tears of excitement. The couple knelt in front of Wu Tianlin and William at the same time, preparing to kowtow to Wu Tianlin for thanking.
Chapter completed!
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