Chapter 431 Lan Lijuan is a ruthless person(1/2)
As a doctor, I have tried my best, but the outcome is still not good, and this is beyond the control of the doctor.
Chen Qi doesn't have time to feel sorry for other people's wives now, because he received a call that something happened to his own wife.
Lan Lijuan is also an awesome person.
When the drug omeprazole sponsored by AstraZeneca was brought to China by Professor Segel from Karolinska University Hospital in Sweden, Lan Lijuan couldn't help it.
The People's Hospital has specially set up a "Six Internal Medicine Department" for this gastric disease research group, and Lan Lijuan is also the deputy director of the department.
However, there is a lot of preliminary work to be done, such as department staff composition, laboratory setup, research group structure, etc.
There is another doctor who uses the patient as a guinea pig first. Good or bad, illness and pain are all borne by the patient.
There are not a few doctors like this. Many clinical drugs are actually experimental drugs needed by the research team. This situation will still exist even in 2022, especially for patients with rare diseases or cancer.
When doctors use experimental drugs, they not only want efficacy and results, but also monitor adverse reactions and other serious side effects.
Therefore, whether the patient is cured or cured, it has practical clinical significance, but the patient has to bear all the consequences.
But Lan Lijuan is not such a quack. She has a strong desire to experiment on her own body first.
The problem now is that Lan Lijuan has checked several times and found that there is no unknown bacterium (called Helicobacter pylori by Chen Qi) on the mucosa of her stomach, so there is no way to "feed the tiger" with her own body.
In the laboratory.
Professor Segel, Professor Zhang Chunyi and Lan Lijuan, who had just arrived in China, sat together and discussed how to carry out clinical work.
Segel thinks China is really a paradise, why?
Because if he wants to conduct a clinical project in Sweden, he must first find the sponsor father, then report it to the health authorities, and also need approval from the hospital's upper management.
It is not enough to go through layers of approval. Patients must have informed consent before the experiment.
The research team that has prepared so hard will face the outcome of a patient refusing to participate.
It costs nothing to treat diseases, and there is no shortage of money, so why should we take certain risks to participate in clinical trials? What if we die or become disabled?
Okay, even if you successfully carry out the clinical trial, you must be extremely careful and prepare all the documents, including the consent and signature documents of the family members and the patient themselves.
Moreover, the entire process must strictly follow the reporting process, and there must be no mistakes, otherwise the consequence will be the intervention of the Medical Ethics Committee.
The most terrifying thing is the lawsuit from the patient. If it is effective, it is easy to say, but if it is not effective or has side effects, the patient will definitely sue and sue you to death.
Once you lose this kind of prosecution, the fine will definitely bankrupt your doctor.
It's useless even if you sign the informed consent form. Rogue lawyers will exploit countless legal loopholes to find procedural errors in you, and then accuse you of obtaining the patient's consent through deception. The agreement should be invalidated.
This is why developed countries in Europe and the United States are so fond of going to poor countries in Asia, Africa and Latin America to conduct clinical drug experiments, including genetic modification.
As a result, Professor Segel was dumbfounded when he arrived in China. Why did he arrive more than two months late, when both Vietnam and China had already established departments?
The foreigner had to give a thumbs up and shout "Yaxi", oh wait, he should shout "Nas".
Among the three partners in the research team, our original plan was that Professor Zhang Chunyi would be in charge of outpatient admissions, and Lan Lijuan would be in charge of the ward.
Professor Segel and his team conducted laboratory tracking research.
But there is also a question here, what kind of patients are you going to treat? You can’t just admit all the patients with stomachache, right?
You must know that the quadruple therapy secretly revealed by Chen Qi is not effective for all gastric diseases. Of course, clinical drug experiments need to be targeted.
But no one has experience in all this.
Previously, Lan Lijuan and Zhang Chunyi searched for Helicobacter pylori in gastric mucosal specimens from patients with internal gastric diseases, and the positive rate was still very high.
But there is a premise. There are about 50 patients in a department, and not everyone has the financial ability to do a gastroscopy.
Gastroscopy was a rare commodity in central Vietnam in 1986, even in provincial capitals, and the high cost of examination alone deterred many patients.
Generally, only patients with severe gastric problems or those with strong economic strength will undergo gastroscopy and microscopic biopsy.
So how to select patients and determine which patients are suitable for the research group?
The most critical point is, does the clinical medication have any effect? How long does it take to take effect? How to operate the process? How to explain it to patients and their families?
Chinese people are easy to bully, but as this is a Sino-foreign cooperation project, and Lan Lijuan and Zhang Chunyi are both doctors with a bottom line, of course they want to have first-hand information first.
How to master this first-hand information was placed in front of the three of them.
Lan Lijuan gritted her teeth and said:
"I have a suggestion. We currently have a lot of cultured Helicobacter pylori specimens in our experiments, so I think I can swallow these bacilli so that we can fully observe how Helicobacter pylori causes disease and how it destroys the stomach.
Mucous membrane.
When we get the first-hand information, we will carry out targeted treatment. Not only can we test the effects of omeprazole and antibacterial drugs, we can also track the changes in the gastric mucosa throughout the entire process, from onset to cure, and master first-hand information.
."
As soon as Lan Lijuan said this, not only Professor Zhang Chunyi and Professor Segel were stunned, but also the young doctors from both China and Sweden in the conference room were dumbfounded.
Drinking bacteria grown in the laboratory?
Just thinking about it makes my skin crawl.
And it’s not just disgusting, it’s also very dangerous. How can bacteria and viruses be so easy to touch? Don’t forget the 731 units back then.
Professor Zhang Chunyi looked at his student and was the first to object:
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"No, I don't agree with you doing this. What should you do if something happens to you? Any unknown bacteria or viruses are uncontrollable."
Professor Segel also objected: "Lan, I know you are a great doctor, but this is too risky. We can completely pay patients to drink bacteria. I believe there will always be people willing to help."
Foreigners are so direct when speaking, just use money.
Lan Lijuan is a very thoughtful person, and even Chen Qi cannot change the things she decides.
She smiled and said easily:
"Teacher Zhang, Professor Segel, in fact, before the meeting, I had taken a sample of Helicobacter pylori orally."
"What?"
"what"
Professor Zhang was frightened, grabbed Lan Lijuan's hand and blamed her eagerly:
"You damn kid, why are you so brave? If something happens to you, how will I explain it to Comrade Chen Qi?"
Lan Lijuan smiled with a relaxed expression:
"With you and Professor Segel here, there is no stomach problem that I'm afraid of. I believe you can help me cure it. Now is not the time to be surprised. Let's seize the time to start the project.
I have saved the gastric mucosal specimens before taking the bacilli orally. Now I need to immediately study the changes in the gastric mucosa on the first day after Helicobacter pylori infection. Come on, everyone takes action."
It has become an established fact. We are all high-level intellectuals. Reason has overcome emotion and we will start working immediately.
Lan Lijuan changed from a doctor and researcher to the role of a patient, and had to endure the pain of gastroscopy every day.
The gastroscopy in the 1980s was still relatively primitive. It was just a thick and long tube inserted into the stomach, and there was no TV screen to follow the whole process.
Doctors who perform gastroscopy must use their eyes to see, just like looking at the lens of a SLR camera.
After reading it, there were no computer screenshots, so I had to record everything by hand.
This time Professor Segel brought Sweden's most advanced gastroscope, with a camera connected to the other end, which can take pictures of partial images within the field of view, which is very helpful for scientific research.
After Lan Lijuan took Helicobacter pylori orally, she felt nothing on the first day.
The next day, apart from feeling a little nauseous, I didn't feel any pain.
This left the members of the tracking research team a little confused, and at the same time they began to worry.
If Lan Lijuan never gets sick, does it mean that Helicobacter pylori is not pathogenic? It does not damage the gastric mucosa?
The research team will be in big trouble. Aslila has reason to suspect that this is an act of defrauding scientific research funds. At the same time, the Chinese doctors and Professor Segel will become a joke in the international medical circle.
Others are anxious, but not as anxious as Lan Lijuan.
She is the initiator of the research team and the discoverer of Helicobacter pylori. If it is proven that the direction of the research team is wrong, then she will really have no shame in facing Mr. Jiang Dong.
As for the other members of the research team, they are all young and middle-aged backbone technical teachers or doctors from Haidong Medical University. They came to Yuezhong People's Hospital for the high subsidies from the research team.
If your research team is disbanded, they will suffer huge losses. I don’t know when the plan to replace the color TV will be realized.
Just when everyone was anxious and looking forward to it, it finally lived up to expectations.
On the third day, Lan Lijuan had stomach pain, and the pain suddenly started in the middle of the night. She felt a burning sensation in her stomach, and the pain radiated to her back.
The symptoms are actually similar to those of myocardial infarction. If Lan Lijuan was not a professional doctor and had taken Helicobacter pylori orally, she would have had to have an electrocardiogram overnight.
Lan Lijuan is a very strong woman. Even if she woke up with a stomachache, she did not say a word.
Instead, I kept feeling the feeling, characteristics, patterns and accompanying symptoms of stomach pain in my mind. Then I quietly got up, turned on the desk lamp, and hunched over to endure the pain, I recorded it in my scratch pad.
At this time, Chen Qi was fast asleep on the bed.
Lan Lijuan knew that Chen Qi had been worried about a mother and son suffering from cancer during this period, so she had no intention of waking him up.
Some people say that doctors should not marry another doctor when marrying, but should choose other professions. In fact, in real hospitals, doctors prefer to find spouses who are also medical staff.
Why?
To be continued...