Chapter 473 Resignation and Responsibility!(1/2)
Chapter 473 Resignation and responsibility!
That chapter was blocked yesterday...
Lu Cheng did not directly explain that plasmids that can load existing anti-specific targets would appear to be unfounded.
And unfounded guidance, whether in front of one's own students or in front of Zhou Linli, Ji Mo and others, makes no sense and will instead leave them with a lot of doubts.
The reason why experiments can explain and discover nature is that they have strong logic in themselves.
From nothing to something, from one to two, from cause to effect.
There is inherent logic in first discovering the phenomenon and then deducing the essence.
Moreover, there are many ways to load specific target antagonist drugs. Although plasmid antagonism is a better method, it does not rule out that other methods are definitely inappropriate.
But no matter what, as long as the current experiment goes smoothly, Lu Cheng will be able to step down from his current mission as commander-in-chief very quickly without any accidents.
Now that he has discovered a pathway and a highly adaptable target, the subsequent drug development, late-stage experiments and other processes can be completely taken over by others.
This will definitely be a very long-term battle process and cannot be accomplished in a day or two.
As for these time-consuming verification processes, Lu Cheng no longer needs to be locked here, and Lu Cheng can also be given a holiday.
After all, it has been more than a month since Lu Cheng first discovered traces of VI. Although the current VI situation is still severe, the early discovery and multiple sources were discovered early, so the response was quite timely.
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In addition, vaccines are available as soon as possible, which is another important means to deal with VI.
"Okay, teacher."
"Okay, Teacher Lu."
"Okay, Lu Cheng." After Dong Zhen and others got the final result and Lu Cheng gave them the next step, they hurriedly retreated.
They know that Lu Cheng is not a god, but Lu Cheng is the soul of this laboratory. From the beginning of the formation of this team, Lu Cheng has always only given guidance in the direction, and they are implementing the specific details.
They first filled in the details according to the direction given by Lu Cheng, and then continued to discuss with Lu Cheng, constantly changing the details, and then determined the direction and the specific steps to reach the direction.
In this process, they not only learned the corresponding operating skills, but also immersed themselves in the process of conducting research on an unknown topic from scratch.
This is the most precious wealth.
Experience, experience.
They are two different concepts, but both are equally important.
Ji Mo and others began to continue the process of filling in the details of the next topic.
Lu Chengcheng told Fang Nixin about this matter immediately.
Fang Nixin is still isolated in her laboratory, and she will also conduct some small experiments herself. The small experiments she conducts are mainly to cooperate with Ji Mo and others to do some experiments that they have no time to do, or do not have time to do.
Little filling.
Fang Nixin spends more time processing data.
Because her grasp of the entire subject is ahead of Ji Mo and others. Since Fang Nixin wants to be Lu Cheng's partner, she naturally wants to understand the progress of the research team and be ahead of the current progress.
of.
Now, she has begun to think about how to seek benefits and avoid harm if this target is harmful to human cells.
Although she had done a lot of things and thought a little ahead of her time, it didn't hinder Fang Nixin from jumping for joy when she heard the news: "Really? Lu Cheng?"
"Are the experimental results so powerful?"
"I specially made a count of the control group. Without any drug intervention, the reproduction multiple of VI in 10 days is about 10 to the third power!"
"This is exponential growth and extremely terrifying."
"Furthermore, if there are enough infected cells in the first generation, they will fill the entire culture bottle within 5 days, and then they will pile up with each other and form clumps around the seventh day, and then quickly consume the nutrients in the culture medium and continue one after another.
Lysis."
"But now our processing result is 1.75!"
"It's equivalent to reducing the reproduction rate to one thousandth."
"If applied properly, this target is very feasible." Fang Nixin is a very knowledgeable person, so she is very excited.
This will definitely be a groundbreaking move that will shock everyone for their team. Fang Nixin is also a participant, and during the whole process, Fang Nixin does not feel that she is just a soy sauce, her own contribution,
Second only to Lu Cheng.
She was not taken away.
This sense of accomplishment is naturally unimaginable to ordinary people.
Lu Chengdao: "Yes, but it is extremely difficult to construct a carrier that can carry specific target antagonist drugs into the body."
"We must also consider that if there are any defects in this carrier, it will be an unimaginable blow to some cells in the human body!"
"The side effects are no less than those of chemotherapy."
In addition to considering the applicability of this target, Lu Cheng naturally also considered its limitations.
Why are today’s cancer chemotherapy drugs not very effective? One reason is that they are not very effective in inhibiting or killing tumors. Another reason is that they are also harmful to the human body and kill specific targets when they see them.
No distinction between friend and foe.
Some CA patients cannot tolerate the chemotherapy process.
Moreover, the target specificities of CA in different people are different, so naturally they cannot be treated in the same way.
Fang Nixin then nodded and said, "Well, this matter needs to be done slowly. We have found the existing specific target and such a strong anti-VI effect, and we have achieved the goal of our research group."
"As for subsequent drug development, etc., it must be left to people at a higher level. This is not something we can contact now."
Now, Lu Cheng and Fang Nixin's research group can definitely apply for the corresponding patent, and they will definitely apply for it. However, Lu Cheng and Fang Nixin do not intend to retain the subsequent use of this patent.
.
Because VI is not a conventional disease, it is a catastrophic one.
This kind of wealth is not easy to make.
"Lu Cheng, do you think it's possible for us to be included in the textbooks?"
"History?" Fang Nixin suddenly asked.
When Lu Cheng heard this, he shook his head and said, "It depends on how you deal with VI. If you can, just do it. If you can't, then don't."
"Fang Nixin, I'll talk to you later. I'll call my master first and tell him the good news." Lu Cheng then interrupted the chat.
Fang Nixin also nodded simply: "It should be."
After Lu Cheng hung up the phone, he dialed Lin Hui's number.
Lin Hui was sipping tea at the moment, so he was in a very good mood: "Xiao Lu, I haven't called you for two days. How are you now?"
"The results have come out, Master."
"The inhibitory effect of this specific target is very strong, reducing the reproduction rate by at least 1,000 times!" Lu Cheng said calmly.
Lin Hui immediately became very loud: "How much did you say?"
Lin Hui thought he heard wrongly.
Generally speaking, the initial drugs should not be therapeutic drugs, but should be auxiliary therapeutic drugs, which can prolong the reproduction cycle of VI and prevent its rapid reproduction and serious illness, which is excellent.
Lin Hui has done drug research on bone tumors before, so he is very familiar with this aspect.
And such drugs can extend the reproduction cycle to ten times the previous time, which is incredible. Most of them are 5-7 times.
Because the general cell culture cycle for basic experiments is only about three days.
The reproduction cycle is extended by more than 50 times, making it a relatively sensitive drug.
If it is more than 100 times, it is a special medicine.
"About 1,000," Lu Cheng said.
Lin Hui understood what he heard this time. He was stunned for a moment, and then asked: "Lu Cheng, let's have a private chat between master and disciple. You haven't reported this matter to your superiors yet, right?"
"Let me ask you, have you found the normal structural target of the cell?"
Lin Hui's question makes sense. Normal cells are eukaryotic cells, with mitochondria and nuclei.
If Lu Cheng is looking for this kind of target, then let alone 1,000 times, 10,000 times can be done, just use a nuclear bomb level to push everything flat.
But such an experiment is meaningless.
It would be too simple if one could only consider whether the pathogen would die when treating a disease, without having to consider whether the person would die.
There simply aren’t too many ways.
Then why do you need medicine? Physical therapy is enough.
Bake it at 1000 degrees high temperature and shoot it with super strong ultraviolet rays for 30 minutes!
Let alone VI, even CA, Iron Man will die.
VI must die.
To be continued...