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Chapter 301 The Years of War (2)

After breakfast, Shao Yuanyi said goodbye to his wife, and then rode on his horse to the dock. At this time, a small inland steamer transporting goods to Forage Ridge was about to return. Shao Yuanyi took out an invitation letter from the Institute of Chemistry of the Academy of Natural Sciences, and with this letter, he could take any domestic transportation to his destination for free. Sure enough, after reading his invitation letter, the captain gave him respectfully into the cabin.

There were three people sitting in the cabin, one of whom was an officer, one was a businessman, and the other was wearing black skin, which looked like an investigator of the plum agency. A Malay sailor carefully brought everyone a pot of mate tea and a few wooden cups, and then left carefully. Shao Yuanyi glanced at it and found that some peanuts from South Africa were usually served with mate tea, but now it has obviously been cancelled. Damn war! Shao Yuanyi cursed that the peanuts were gone, but the fare did not drop. Fortunately, I didn't have to spend money.

Regarding the passengers he was traveling with, Shao Yuanyi tactfully did not talk much to them. After spending a long time in the shaking cabin, he woke up and suddenly found that he had arrived at the Ping'an Port Pier. After stretching hard, Shao Yuanyi picked up his handbag and strode to the pier.

The dock is full of steam steam cranes that are spitting black smoke. These powerful cranes lift heavy raw materials such as iron ore sand into the steam train compartment parked by the dock. Whenever several compartments are filled, these small horsepower low-speed locomotives slowly start and transport several trucks of iron ore sand to the iron smelting workshop of Ping'an Steel Plant through the factory railway.

In addition to these trains that transport raw materials, sometimes there are some flat-panel trains that bring various industrial finished products to the dock. These industrial finished products are varied and have everything, but most of them are relatively bulky objects, such as rails, artillery, steel armor, steam engines, boilers, machinery and other products.

Sometimes, some ships in Ping'an Port carry cargo to Ping'an Machine Weaving Factory, the upper reaches of Ping'an River - the factory with the highest profitability in China. Most of these ships are shipped with food or fuel, but a few ships are shipped with soda ash, dyes and other chemicals, which are important raw materials to be used in the textile process.

Over the years, with the development of the domestic chemical industry, especially after a considerable number of outstanding junior high school graduates entered the only high school in China, the Affiliated High School of the Institute of Natural Sciences, after several years of systematic study, both inorganic and organic chemistry have made great progress. Thanks to the only two chemistry teachers among the people (one worked in the Institute of Chemistry of the Institute of Natural Sciences, and the other taught in the Corps Fort). The number of students studying chemistry knowledge in China has finally reached a relatively high number in the past two years. The total number of students studying this knowledge in the affiliated middle schools and Corps Fort has reached more than 120.

Most of these students are assigned to several companies, such as Northern Chemical Factory, Northern Pharmaceutical Factory, Northern Arsenal, Coking Factory, Dye Factory, Ping An Iron and Steel Factory, etc. After several years of training, their performance is still sloppy, which greatly relieves the time travelers, because it means that their career successors are in succession.

Among the various categories of East Coast chemical industry, it seems that the achievements have been made in the field of coal chemical industry. Through countless experiments, East Coast people's research on various components of coal tar has reached a very detailed level, especially in the dye industry. Through continuous experiments and arrangements, East Coast people have now created dozens of colors of dyes, making the advantages of East Coast textiles in the high-end field (dyed cloth, printed cloth). If it weren't for some important intermediate chemicals such as potassium dichromate, etc., that the dye industry on East Coast can really achieve great development, and the output can be doubled by at least dozens of times, completely monopolizing the entire textile market - well, this seems not a good thing for East Coast people.

In addition to dyes, the coal tar gas exported from the coking plant also has a large amount of coal gas, which can be used asphalt. In addition, two former middle school students also brought several "students" to successfully produce acetic acid (acetic acid) through calcium hydroxide and sulfuric acid. This has further expanded the utilization rate of coal tar.

However, the Institute of Chemistry of the Natural Science Institute invited Shao Yuanyi to Ping'an County (the location of the Institute of Chemistry). This was not for the sake of coal tar, dyes, or other things. Their organic chemistry department finally successfully restored a gadget - a drug called aspirin. Many doctors with a certain status and reputation in China, including Shao Yuanyi, were summoned to Ping'an County Chemistry Institute. Each of them would be given some aspirin, and then taken back to the patients to take them in detail and record various situations in detail, and finally feedback them to the people of the Institute of Chemistry. After the final confirmation that there was no problem, the aspirin could be handed over to the Northern Pharmaceutical Factory for experimental production.

Speaking of which, when Wang Liao, the only genuine doctor in the traveling world, suddenly proposed whether he could try to reduce the classic drug aspirin, ten years ago, the Ministry of Health began to conduct research with the Institute of Chemistry. However, at the beginning, this research progressed very slowly in the absence of people, objects, and data. What is even more amazing is that Wang Liao, the proposer, only vaguely understood the general process of aspirin production in modern drug production. Regarding the original origin of this drug, this guy didn't know whether he didn't listen carefully or what happened. He only knew that it was a certain important ingredient salicyside extracted from willow bark, and then acetic acid and other synthetic drugs.

The speechless chemistry people could only study it themselves. Fortunately, Song Qiang, who was a chemistry teacher in high school, took the time to recall the knowledge about aspirin he had learned. However, when he taught students to do experiments, he had all had ready-made raw materials such as salicylic acid and acetic anhydride. As for how these raw materials came from, it was quite difficult. Because modern drug production, including raw materials, are basically artificially synthesized, but time travelers obviously do not have these conditions at present, so finding alternatives from nature has become an inevitable choice. At this time, the willow bark mentioned by Wang Liao, a half-baked doctor, came into everyone's eyes.

The process of synthesizing salicylic acid was finally successful after countless failed tests. First, at the beginning, everyone lacked qualified glass test vessels. Later, after the quality of the test vessels in Henan Glass Factory passed, everyone started serious research, which wasted a year or two. Then it took a lot of time to separate, identify and purify salicylic acid from the willow bark. After that, there is also the problem of how to hydrolyze salicylic acid and oxidize it into salicylic acid. This often has a small detail that can hinder everyone for several months or even a year.

After successfully purifying salicylic acid from willow bark and then making salicylic acid, we began the long journey of preparing another important raw material acetic anhydride, which was another painful process. We first made acetic acid (i.e. acetic acid) from coal tar, and then decomposed and dehydrated at high temperature to form vinyl ketone. As for the control of temperature here, the necessary reaction conditions made everyone spend countless time in a desperate situation, and finally got what everyone wanted.

After vinyl ketone is produced, it reacts with acetic acid under the catalyzed by concentrated sulfuric acid to form acetylsalicylic acid, i.e. aspirin. This process is easy to say, but it contains quite a lot of difficulties and attention points. Any error in any place may lead to the failure of the test. Everyone's test records have filled a whole box, which shows the difficulties of the process.

Aspirin was finally made into the first batch of samples the year before yesterday, which took more than six years. After the first batch of drugs came out, I found that the effect of this drug was not very good. After that, everyone spent more than two years to continuously improve the drug preparation process, and in the meantime, they also kept asking Guarani to do human trials. It was not until August this year that this drug finally achieved a very high efficacy.

At this time, people from the Institute of Chemistry and the Ministry of Health summoned Shao Yuanyi and other doctors to bring back the drugs prepared in the laboratory for long-term clinical trials to finally confirm their effect. If the response is good, then the northern pharmaceutical factories can start the technical research required for industrial production - in fact, they have already started doing this.

Shao Yuanyi finally came to the Chemistry Institute at noon. After greeting several officials familiar with the Ministry of Health, Shao Yuanyi was taken to the laboratory. A young top student (high school student) handed him a batch of drugs contained in a wooden box, and explained the characteristics and uses of the drug to him in detail, and then took him back for clinical trials and recorded the process in detail.

Shao Yuanyi naturally nodded to this. In fact, he was extremely interested in this drug. Its efficacy was so significant and could cure so many diseases. He really wanted to rush back and find some patients to try it out immediately. If it was really effective, it would be a great merit and a powerful tool for money. If it was sold openly, it might make more money than textiles.

Of course, selling openly may be another disaster, and it is hard to say. A big tree attracts wind. The East Coast people are already so conspicuous and have so many ways to make money. If they can still make money by selling medicine, wouldn’t they force Europeans to collectively steal you?

After saying goodbye to the officials of the Ministry of Health, Shao Yuanyi hurried back to the dock and prepared to take a boat to return to Wucaoling Township. Now it is the war years, and the family still has a lot of things to be busy with, so we can't wait outside for too long.
Chapter completed!
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